Semaphorin 3c Is An Androgen Receptor-Regulated Gene

Prostate cancer (PCa) is the second leading cause of cancer-related deaths in North America. The androgen receptor (AR) is a member of the nuclear receptor superfamily of transcription factors and is heavily implicated in PCa progression. First-line therapies frequently target the AR axis and are initially met with favourable response but restored and aberrant AR signaling fuel disease progression to stages for which treatment is palliative. Transcriptional targets of the AR include genes involved in cell growth and cell fate but are not completely described. The semaphorin family of signaling proteins is a large grouping of cell-surface or secreted signaling proteins that function in neurogenesis and development. The roles of semaphorins in cancer are becoming increasingly evident however mechanistic details surrounding their involvement in cancer are poorly defined. One member of the class 3 semaphorins …