Nci Office Of Cancer Genomics: Generating Publicly Available Data And Resources For The Advancement Of Precision Medicine

The Office of Cancer Genomics (OCG), within the National Cancer Institute, supports cutting-edge genomics and translational research to advance the molecular understanding of cancer, with the ultimate goal of improving clinical outcomes through precision medicine. OCG-supported cancer research initiatives generate and analyze comprehensive genomics datasets, and translate these data into tools, resources, and clinically-relevant information. OCG currently supports three complimentary initiatives, each uniquely collaborative and innovative. The Cancer Genome Characterization Initiative (CGCI) and the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) Initiative collect high quality, clinically annotated, tumor and normal matched tissue samples for both discovery and validation cohorts. These initiatives aim to identify therapeutic targets and biomarkers in some malignancies prevalent in HIV-positive individuals and high-risk pediatric cancers. Samples are analyzed by whole genome, whole exome, and transcriptome sequencing and datasets are available to the research community in ways that protect patient privacy. The Cancer Target Discovery and Development (CTD⁁2) Network combines computational approaches, high-throughput functional assays, and high content small molecule and genetic screens to accelerate the translation of genomic data into discoveries that will inform patient-specific cancer treatments. The Network develops bioinformatics and analysis tools, generates diverse datasets, and further validates subsets of these data. All resources, datasets (https://ctd2.nci.nih.gov/dataPortal/), and validated results (http://ctd2-dashboard.nci.nih.gov/) are openly available to the research community. Data, analytical tools, and resources generated by OCG initiatives are made publicly available and can be accessed through the OCG website (https://ocg.cancer.gov/). Investigators can use and analyze the data according to their research interests. In addition, datasets generated by OCG-supported programs can serve as valuable resources for those seeking to validate genomic findings. For this poster presentation we will present the most up-to-date information about what data and resources are available, and how to access them. The use of OCG datasets and resources by the research community will further the collaborative goal of enabling precision medicine in the clinic. Citation Format: Nadia L. Jaber, Jessica N. Mazerik, Jaime M. Guidry Auvil, Subhashini Jagu, Nicholas Griner, Martin Ferguson, Daniela S. Gerhard. NCI Office of Cancer Genomics: Generating publicly available data and resources for the advancement of precision medicine. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 5293.