A Model for Cell Killing Using Radiolabelled Antibodies

A mathematical model has been constructed to determine the dose to solid tumours from tumour seeking antibodies labelled with beta emitting isotopes. Although high tumour uptake of isotope yields high tumour doses, operation of the model has identified the residence time of the isotope within the tumour and normal tissues as a critical factor determining specificity of tumour dose. This finding is open to experimental verification and analysis using the wide range of isotopes which may be bound to chelate labelled antibodies.