Dermatophagoides pteronyssinus group 2 allergen bound to 8-OH modified adenine reduces the Th2-mediated airway inflammation without inducing a Th17 response and autoimmunity

•8-OH modified adenine bound to Dermatophagoides pteronyssinus group 2 a novel allergen-TLR7 agonist conjugate, ameliorated the murine airway inflammation.•The conjugate induced the shifting of Th2 cells into Th1/Tr1 cells producing IFN-γ, IL-10, but not IL-17A, in a nDer p2-driven model of airway inflammation by using both priming and therapeutic protocol.•The conjugate induced pro-Th17 cytokines by BMDC, but the IL-10 upregulation was able to block Th17 cell development.•The conjugate did not promote autoimmune response with B cell expansion and production of autoantibodies in a long-term protocol of airway inflammation.•The conjugate represents a novel and safe adjuvant for immunotherapy.