Interleukin-10 attenuates tumour growth by inhibiting interleukin-6/signal transducer and activator of transcription 3 signalling in myeloid-derived suppressor cells

Bo-Ra Lee,Bo-Eun Kwon,Eun-Hye Hong,Aeri Shim,Jae-Hyoung Song,Hongmin Kim,Sun-Young Chang,Yeon-Jeong Kim,Mi-Na Kweon,Je-In Youn,Hyun-Jeong Ko

Cancer Letters（2016）

引用 31|浏览30

暂无评分

摘要

•IL-10-deficiency accelerated tumour growth via the up-regulation of IL-6.•IL-6R blockade and STAT3 inhibitor reduced tumour growth and MDSCs.•STAT3 inhibitor attenuated MDSCs expansion and suppressed IL-6 overproduction in IL-10-deficient mice.

查看译文

关键词

Cancer,Interleukin-6,Myeloid-derived suppressor cells,Interleukin-10,Signal transducer and activator of transcription 3

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要