Des-acyl ghrelin inhibits the capacity of macrophages to stimulate the expression of aromatase in breast adipose stromal cells

CheukMan C. Au,Maria M. Docanto,Heba Zahid,Francesca-Maria Raffaelli,Richard L. Ferrero,John B. Furness,Kristy A. Brown

The Journal of Steroid Biochemistry and Molecular Biology（2017）

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摘要

•Des-acyl ghrelin stimulates macrophage M2-specific Cd206, inhibits M1-specific Cd11c.•Des-acyl ghrelin inhibits Ptgs2 and Tnf expression in macrophages.•Des-acyl ghrelin prevents the induction of aromatase in ASCs by macrophages.

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关键词

ASCs,ATMs,CD,Ptgs2,DAG,FCS,GHSR1a,IL,MCP-1,PGE2,PMA,qRT-PCR,TNF

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