Cyclophosphamide Efficacy And Toxicities In The First Line Treatment Of Acquired Hemophilia

Background: Acquired hemophilia is a rare bleeding disorder caused by antibodies against factor VIII. Patients without a personal or family history of coagulopathy may present with significant bleeding symptoms, often later in life. Acquired hemophilia has been associated with pregnancy, malignancy, and autoimmune disorders, but in approximately 50% of cases no clear etiology is identified. The two goals of treatment include control of bleeding and eradication of the antibody. Current recommendations based on data from large registries suggest that cyclophosphamide and high-dose steroids should be the first-line treatment of acquired hemophilia.