E3 ubiquitin ligase: A potential regulator in fibrosis and systemic sclerosis

Xiao-Lei Huang,Li Zhang,Yu Duan,Yu-Jie Wang,Jiu-Hua Zhao,Jing Wang

Cellular Immunology（2016）

引用 12|浏览21

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摘要

•E3 ubiquitin ligases participate in the regulation of TGF-β signaling.•E3 ubiquitin ligases involve in fibrosis through TGF-β signaling.•E3 ubiquitin ligases regulate fibrosis through other mechanisms.•The role of E3 ligases played in SSc may lead to novel pharmacologic therapies.

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关键词

AIP4,α-SMA,BMP,Cbl-b,Co-Smad,dcSSc,ECM,EMT,ER,ERAD,GRAIL,HECT,HSCs,I-Smads,lcSSc,NEDD4,NHBECs,NRCFs,RING,RBR,R-Smads,Smurf,SSc,TβR2

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