Interactions between silica nanoparticles and phospholipid membranes.
Biochimica et Biophysica Acta (BBA) - Biomembranes(2016)
摘要
Silica nanoparticles (SNPs) are widely used for biomedical applications. However, their parenteral administration may induce hemolysis. Molecular mechanisms leading to this effect are still controversially discussed. We therefore used a combination of biophysical techniques to investigate the interaction of hemolytic and non-hemolytic SNPs with model phospholipid membranes.
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关键词
Hemolysis,Silica nanoparticles,Isothermal titration calorimetry,Solid state nuclear magnetic resonance
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