Invasive pneumococcal disease leads to activation and hyperreactivity of platelets

Rahajeng N. Tunjungputri,Marien I. de Jonge,Astrid de Greeff,Saskia van Selm,Herma Buys,Jose F. Harders-Westerveen,Norbert Stockhofe-Zurwieden,Rolf T. Urbanus, Phillip G. de Groot,Hilde E. Smith,Andre J. van der Ven,Quirijn de Mast

Thrombosis Research（2016）

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摘要

Using a novel porcine model of intravenous Streptococcus pneumoniae infection, we showed that invasive pneumococcal infections induce marked platelet activation and hyperreactivity. This may contribute to the vascular complications seen in pneumococcal infection.

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关键词

Platelets,Pneumonia,Streptococcus pneumoniae,Myocardial infarction,Platelet activation,Infection

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