A Facile FeCl3/I2‑Catalyzed Aerobic Oxidative Coupling Reaction: Synthesis of Tetrasubstituted Imidazoles from Amidines and Chalcones

Yuelu Zhu,Cheng Li,Jidong Zhang,Mengyao She,Wei Sun,Kerou Wan,Yaqi Wang,Bin Yin,Ping Liu,Jianli Li

Organic Letters（2015）

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摘要

A facile and efficient route for the synthesis of tetrasubstituted imidazoles from amidines and chalcones via FeCl3/I2-catalyzed aerobic oxidative coupling has been developed. This new strategy is featured by high regioselectivity and yields, good functional group tolerance, and mild reaction conditions.

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