Synergistic effects of negative-charged nanoparticles assisted by ultrasound on the reversal multidrug resistance phenotype in breast cancer cells

Dongxiao Wang,Wanxian Luo,Ge Wen,Li Yang,Shaofu Hong,Shiyu Zhang,Jianxin Diao,Jianguo Wang,Hongqin Wei,Yingjia Li,Ying Wang

Ultrasonics Sonochemistry（2017）

引用 14|浏览18

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摘要

•A negative-charged dual-ligand NP is synthesized but fails to overcome MDR.•Cells treated with US prior to NP improves cytotoxity and eliminates damage from US.•The strategy triggers endosomal escape and affects related proteins in MDR reversal.

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关键词

Multidrug resistance,Negative-charged nanoparticles,Ultrasound,Synergistic effects

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