Polymorphisms in ATP-binding cassette transporters associated with maternal methylmercury disposition and infant neurodevelopment in mother-infant pairs in the Seychelles Child Development Study

Karin Engström,Tanzy Love,Gene E. Watson,Grazyna Zareba,Alison J. Yeates,Karin Wahlberg,Ayman Alhamdow,Sally W. Thurston,Maria S. Mulhern,Emeir M. McSorley,J. J. Strain,Philip W. Davidson,Conrad F. Shamlaye,Gary J. Myers,Matthew D. Rand,Edwin van Wijngaarden,Karin Broberg

Environment International（2016）

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摘要

•SNPs in three ABC transporter genes were associated with hair mercury in mothers.•Maternal ABCC1 SNP rs11075290 was associated with child neurodevelopment.•Genetics of ABC may determine prenatal methylmercury concentrations.

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关键词

ABC,ABCB1,ABCC1,ABCC2,BSID-II,MDI,MDR1,MeHg,MRP1,MRP2,NC2,PDI,SCDS,SNP

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