31 Unravelling the Mechanisms of Mental Stress Induced Myocardial Ischaemia

Background Mental stress triggers myocardial ischaemia at cardiac workloads that are lower than those that cause exercise-induced ischaemia in the same patient. Clinical relevance is highlighted by observational studies demonstrating marked increases in cardiovascular events when large populations are exposed to acute mental stress for example by earthquakes and publicised national sports events. In contrast, even in patients with known coronary artery disease and exertional angina, exercise is safe and beneficial. These differences may reflect underlying pathophysiology with vascular dysregulation limiting myocardial blood flow during mental stress. Methods Simultaneous intracoronary pressure and flow velocity data were acquired in a target artery from 15 patients with significant coronary artery disease (FFR u003e0.8 and or stenosis u003e70%) and 11 controls following exposure to mental stress during cardiac catheterisation. Oral nitrate preparations, calcium channel antagonists and beta-blockers were stopped 24–48 h in advance. All data were acquired at rest and at peak mental stress. Mental stress involved a 6-minute mental stress test consisting of mental arithmetic and the Stroop test. Coronary flow average peak velocity (APV), microvascular resistance (MVR) and buckberg index (BI; a surrogate of subendocardial ischaemia) were calculated. Wave intensity analysis also differentiated waves that accelerate and decelerate coronary flow Results Mental stress was associated with an increase in systolic blood pressure (SBP, 28.43 mmHg; p = 0 Conclusions Exposure to mental stress is associated with an increase in myocardial work and oxygen demand that is met by an increase in coronary flow in patients with unobstructed coronaries. Paradoxical microvascular dysfunction in response to mental stress does occur and this abnormal endothelial response appears to correlate with the extent of atherosclerosis in the vessel. This likely plays a key role in the mechanism of mental stress induced myocardial ischaemia and provides an exciting target for future therapies.