Contextual signaling in cancer

Laura J. Smithson,Corina Anastasaki,Ran Chen,Joseph A. Toonen,Sidney B. Williams,David H. Gutmann

Seminars in Cell & Developmental Biology（2016）

引用 7|浏览19

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摘要

•Cellular responses are dictated by context-dependent signaling pathway engagement.•A limited number of molecules can activate multiple downstream effectors.•Specific effector pathways are activated in a cell type and tissue-specific manner.•Extracellular cues and genomic/genetic factors modify signaling pathway output.

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关键词

AKT,ATF4,cAMP,CCL5,CNS,4EBP1,ECM,ERK,GAP,GRK2,HGG,HVR,iPSCs,JNK,MEK,MKK4,MLK3,mSIN1,mTOR,mTORC1,mTORC2,NF1,NLGN3,NSCs,OPG,PDPK1/PDK1,PI3K,PIP2,PIP3,PKCα, β, γ,PKCζ,PNS,PRAS40,Protor,PTEN,Rac1,RAF,Raptor,RAS,Rictor,p90-RSK,SCF,S6K,SGK1,TSC

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