Timing Of Primary Prophylaxis G-Csf Use During Chemotherapy In Elderly Patients With Nhl

Background: Febrile neutropenia (FN) and hospitalizations for infection are serious potential complications of myelosuppressive chemotherapy (chemo) treatment in cancer patients. Primary prophylactic G-CSF (PPG) is often used to decrease incidence of FN in patients at high risk. Due to the potential for G-CSF to stimulate neutrophil precursors at the same time as myelosuppression from chemotherapy, it is recommended that G-C SF be administered 24 hours after chemo administration. In addition, several studies showed that use of G-CSF on the same day as chemo may result in worse FN outcomes. Data are limited describing practice patterns of PPG timing relative to chemo administration in elderly patients with non-Hodgkin’s lymphoma (NHL), overall and by agent.