Site-directed mutants of human RECQ1 reveal functional importance of the zinc binding domain

Furqan Sami,Ronald K. Gary,Yayin Fang,Sudha Sharma

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis（2016）

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摘要

•The zinc binding motif in the RQC domain of RECQ1 is a key structural element.•Cysteine residues that coordinate zinc binding in RECQ1 are critical for the ATPase and helicase activities.•RECQ1 mutants that lack zinc binding retain DNA binding and annealing activities.•Conserved cysteine residues contribute differentially to the RECQ1 structure and functions.

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关键词

RecQ,Helicase,Zinc-binding domain,Mutation,Strand-annealing

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