Glycosylation-dependent binding of galectin-8 to activated leukocyte cell adhesion molecule (ALCAM/CD166) promotes its surface segregation on breast cancer cells.

Marisa M. Fernández,Fátima Ferragut,Víctor M. Cárdenas Delgado, Candelaria Bracalente,Alicia I. Bravo,Alejandro J. Cagnoni,Myriam Nuñez,Luciano G. Morosi, Héctor Ramiro Quintá,María V. Espelt,María F. Troncoso,Carlota Wolfenstein-Todel,Karina V. Mariño,Emilio L. Malchiodi,Gabriel A. Rabinovich,María T. Elola

Biochimica et Biophysica Acta (BBA) - General Subjects（2016）

引用 27|浏览23

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摘要

•Endogenous ALCAM from MDA-MB-231 breast cancer cells interacts with galectin-8.•Exogenous galectin-8 provokes ALCAM segregation and clustering at the cell surface.•ALCAM from MDA-MB-231 cells has high levels of α(2,6) sialylated glycans.•Galectin-8 and ALCAM are co-expressed in normal and malignant human breast tissues.

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关键词

2AB,ALCAM,ALCAMe,ALCAMgly,ALCAMnongly,ADAM17,CM,CRD,DABCO,DCIS,EDTA,EEA1,ER,FBS,FITC,FV,Gal-8,Gal-1,Gal-3,GAPDH,HER2=Her2-neu,HRP,IDC,IL-2,kon,koff,Lys,PBS,PerCP-Cy5.5,PMSF,PVDF,rGal-8,RU,SDS-PAGE,shALCAM,SPR,TDG,TGF-β,WAX

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