Reverse signaling via B7-H1/PD-1 interaction and clinical characteristics of B7-H1 (PD-L1) expressed on multiple myeloma cells

e214 Conclusions: Our results demonstrate the potent, rapid activity of filanesib which induces a cell cycle blockade through the inhibition of KSP, leading to apoptosis in MM. Furthermore, this agent showed significant synergy with pomalidomide and dexamethasone, what supports the clinical ““Pomdefil”” trial, recently activated in the context of the Spanish Myeloma Group (GEM).