Circulating adiponectin: a cardiometabolic marker associated with global cardiovascular risk

Objective This study was designed to evaluate the relationship among circulating adiponectin (ADPN), left ventricular mass (LVM) and cardiometabolic comorbidities in subjects at higher global cardiovascular risk (score of “Cuore Project“).Methods 115 consecutive subjects were grouped according to normal or low ADPN levels. Left ventricular internal diameter (LVID/h), total LV mass (LVM), LVM index (LVMI), relative wall thickness (RWT), LV ejection fraction by echocardiography and diastolic parameters, by pulsed-wave Doppler were calculated.Results Low-ADPN subjects were characterized by a signifi cantly higher prevalence of some cardiometabolic comorbidities (obesity, visceral obesity, diabetes and insulin resistance, LVH, metabolic syndrome (MetS), coronary artery syndrome (CAD). BMI ( P u003c0.0001), WHR ( P u003c0.03), triglycerides ( P u003c0.001), HOMA-IR ( P u003c0.001), LVM, LVMI, IVST and RWT ( P u003c0.0001) were signifi cantly higher and HDL-C ( P u003c0.001) and LVEF were signifi cantly lower in low-ADPN than in norma...