THE CORRELATION BETWEEN SINGLE NUCLEOTIDE POLYMORPHISM OF ABC TRANSPORTER AND RESPONSE RATE AND SEVERE TOXCITY IN LUNG CANCER PATIENTS TREATED WITH PLATINUM-BASED CHEMOTHERAPY

Objective:To investigate the relationship between genetic polymorphisms of ATP-binding cassette (ABC) and the response rate and the occurrence of grade 3 or 4 toxicity in stage III and IV non-small cell lung cancer (NSCLC) patients treated with platinum-based chemotherapy.Methods:A total of 240 patients with advanced NSCLC were treated with cisplatin or carboplatin based on chemotherapy. Clinical response and grade 3 or 4 toxicity were evaluated after two cycles. MDR1 C3435T, MDR1 C1236T, BCRP C421A, MRP2 I1324I and MRP2?24Cu003eT were determined by MASS-ARARY methods. hTe odds ratios (OR) and 95% conifdence interval (CI) were computed by logistic regression.Results:hTe objective response rate to chemotherapy in patients with MRP2?24Cu003eT C/T was higher than that in patients with C/C (P=0.026, OR=3.036, 95% CI: 1.143~8.061). hTe risk of 3 or 4 thrombocytopenia was lower in patients with MRP2 I1324I A/G (P=0.028, OR=6.829, 95% CI: 1.232~37.869) and MRP2?24Cu003eT C/T (P=0.029, OR=6.592, 95% CI: 1.217~35.695).Conclusion: Polymorphisms of MRP2?24Cu003eT and MRP2 I1324I might be used to predict the objective response rate or 3 or 4 thrombocytopenia in patients with advanced NSCLC atfer treatment with platinum-based chemotherapy.