The feasibility of 153 Sm labeled cytosine in tumor imaging

Objective To investigate the application of153 Sm labeled cytosine in tumor metabolic imaging.Methods The cytosine was labeled with153 Sm by DTPA coupled method,the final product was C-DTPA-153 Sm.The labeled product was then purified. The determination of acute toxicity, in vitro stability, plasma pharmacokinetics in rabbits and imaging of cell and in tumor-bearing mice of radiolabeled cytosine were carried out. Results The results of examinations and animal experiments showed that the C-DTPA-153 Sm was free of bacteria,pyrogen and toxic agents,and it could be concentrated at the tumor site in tumor-bearing mice.Conclusion C-DTPA-153 Sm metabolic imaging might be used to evaluate the tumor growing status and may have important clinical value.