The function of Sirt1 in myocardial protection

Sirt1, a member of the NAD+-dependent class III histone deacetylase family, plays an important role in metabolism, aging and apoptosis. In cardiomyocytes, Sirt1 can enhance the resistance of oxidative stress, inhibit cell apoptosis, relieve inflammation, regulate energy metabolism and coordinate the diastolic and systolic function of the heart through deacetylasing some special factors, thus playing a vital role in myocardial protection. This article will summary the signal pathway of sirt1 and the current research progress of Sirt1 in myocardial protection.