Biochemical characterization of human acyl coenzyme A: 2-monoacylglycerol acyltransferase-3 (MGAT3).

Curtis Brandt,Pamela J. McFie,Scot J. Stone

Biochemical and Biophysical Research Communications（2016）

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摘要

•MGAT3 possesses both MGAT and DGAT activities.•MGAT3 expressed in cells stimulates lipid droplet growth.•Unlike DGAT2, MGAT3 remains in the endoplasmic reticulum and does not interact with lipid droplets.•MGAT3 is a more stable protein than DGAT2.•MGAT3 is ubiquitinated and degraded via the proteasome.

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关键词

Triacylglycerol,Diacylglycerol,Monoacylglycerol acyltransferase,Diacylglycerol acyltransferase,Lipid droplet

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