Clinical and epidemiological features of acute hepatitis B in adult patients

Objective To analyze the epidemiological features of acute hepatitis B in adult patients in order to offer advice for the prevention and treatment of adult acute hepatitis B.Methods One hundred and nine patients with acute hepatitis B in our hospital from Jan.2009 to Dec.2012 were enrolled.Data of these cases(e.g.the epidemiological data,serum HBV markers,liver function and clinical outcome)were analyzed retrospectively.Results Most patients were males,for the male and female ratio was 5.06:1.The major patients were at age from20 to 59,accounting for 93.57%.Most patients didnu0027t have received hepatitis B vaccine or a quite clear history of vaccination(96.34%).Sexual contact transmission(24.77%)was one of the important ways,with a total of 27 cases.Incidence of adult acute hepatitis B had been on the rise year by year.Liver function of patients in the early stage was impaired severely.For most patients,acute hepatitis B began with acute jaundice,and had long course with favourable prognosis at the rate of 94.50%.The anti-HBc IgM level in all patients on admission was 20.38±8.41S/CO,HBV DNA4.27±1.12lg10 copy/L,ALT1404.98±906.22U/L,TBIL95.24±69.03μmol/L,respectively.It took22.87±10.16 days for liver function to return to normal,13.87±10.14 days and 10.05±9.66 days for serum HBsAg and HBV DNA to turn negative,respectively.Conclusion The incidence of adult acute hepatitis B is on the rise.Sexual transmission is currently one of the important routes to the spread adult acute hepatitis B.Vaccination of hepatitis B in the adults and high-risk groups might contribute to the reduction of adult acute hepatitis B.