Salivary caffeine concentrations are comparable to plasma concentrations in preterm infants receiving extended caffeine therapy
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY(2016)
摘要
AimsCaffeine concentrations in preterm infants are usually measured in the blood. However, salivary assays may provide a valid and practical alternative. The present study explored the validity and clinical utility of salivary caffeine concentrations as an alternative to blood concentrations and developed a novel plasma/salivary caffeine distribution model. MethodsPaired salivary and plasma samples were obtained in 29 infants. Salivary samples were obtained using a commercially available salivary collection system. Caffeine concentrations in the saliva and plasma were determined using high-performance liquid chromatography. A population pharmacokinetic (PK) model was developed using NONMEM 7.3. ResultsThe mean ( standard deviation) gestational age (GA) at birth and birth weight were 27.9 +/- 2.1weeks and 1171.6 +/- 384.9g, respectively. Paired samples were obtained at a mean postmenstrual age (PMA) of 35.5 +/- 1.1weeks. The range of plasma caffeine concentrations was 9.5-54.1gml(-1), with a mean difference (95% confidence interval) between plasma and salivary concentrations of -0.18gml(-1) (-1.90, 1.54). Salivary and plasma caffeine concentrations were strongly correlated (Pearson's correlation coefficient=0.87, P<0.001). Caffeine PK in plasma and saliva was simultaneously described by a three-compartment recirculation model. Current body weight, birth weight, GA, PMA and postnatal age were not significantly correlated with any PK parameter. ConclusionsSalivary sampling provides an easy, non-invasive method for measuring caffeine concentrations. Salivary concentrations correlate highly with plasma concentrations. Caffeine PK in saliva and plasma are well described by a three-compartment recirculation model.
更多查看译文
关键词
caffeine,pharmacokinetic model,preterm infant,saliva
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要