Virologic Characterization And Association With Disease Progression In Children With Hepatitis B Virus Bcp/Pc Mutants

trend that the older the age, the higher the positive rate (p u003c 0.0001). HEV RNA was detected in 2 (0.23% [0–0.56%]) participants. One of them could be sequenced over the entire genome and classified as genotype 4. This isolate was close to the swine China strain (swGX40) with 95.6% identity, and had the same length of ORF1, ORF2, and ORF3 as swGX40 and coded for 1,705, 674, and 114 amino acids, respectively. Another HEV RNA positive sample was classified as genotype 3 from a partial ORF1 genome sequence. New HEV infection developed in 1 of the 54 subjects (19 males and 35 females) who participated in our survey twice. The incidence of HEV infection was calculated to be 6.43/1,000 person-years [0.16– 35.8/1,000 person-years]. Conclusions: Our study showed that the new HEV infection occurred frequently among the general population in Cambodia. This is the first report that HEV genotype 3 and 4 detected from people living in Cambodia.