Role of the Cys154Arg Substitution in Ribosomal Protein L3 in Oxazolidinone Resistance in Mycobacterium tuberculosis.

Gaelle Makafe,Yuanyuan Cao,Yaoju Tan,Mugweru Julius,Zhiyong Liu,Changwei Wang,Moses Njire,Xingshan Cai,Tianzhou Liu,Bangxing Wang, Wei Pang,Shouyong Tan,Buchang Zhang,Wing Wai Yew,Gyanu Lamichhane,Jintao Guo,Tianyu Zhang

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY（2016）

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摘要

We expressed the wild-type rplC and mutated rplC (Cys154Arg) genes, respectively, in Mycobacterium tuberculosis H37Ra and H37Rv in an attempt to delineate the role of rplC (Cys154Arg) regarding oxazolidinone resistance. An increase of the MICs of linezolid (LZD) and sutezolid (PNU-100480, PNU) against the recombinant mycobacteria with overexpressed rplC mutation (Cys154Arg) was found, suggesting the rplC gene is a determinant of bacillary susceptibilities to LZD and PNU.

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