Berberine inhibits inflammatory mediators and attenuates acute pancreatitis through deactivation of JNK signaling pathways

Sun-Bok Choi,Gi-Sang Bae,Il-Joo Jo,Shaofan Wang,Ho-Joon Song,Sung-Joo Park

Molecular Immunology（2016）

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摘要

•Berberine inhibited cerulein-induced acute pancreatitis.•Berberine inhibited activation of the JNK signaling pathways in acute pancreatitis.•Berberine inhibited inflammatory mediators production in acute pancreatitis.•Berberine exerts anti-inflammatory effects on acute pancreatitis.

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关键词

AP,BBR,CCK,HPRT,H&E,IHC,Iκ-Bα,IL,iNOS,JNK,MAPK,mRNA,NF-κB,PBS,SAP,TNF

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