Mismatch repair enhances convergent transcription-induced cell death at trinucleotide repeats by activating ATR.

Nimrat Chatterjee,Yunfu Lin,John H. Wilson

DNA Repair（2016）

引用 8|浏览6

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摘要

•Mismatch repair pathway enhance convergent transcription-induced cell death at CAG repeats.•MutSβ and MutLα act in the same pathway to induce cell death during convergent transcription.•MSH2, MSH3 and MLH1 activate ATR at CAG repeats during convergent transcription.

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关键词

Mismatch repair,Convergent transcription,ATR DNA damage response,Trinucleotide repeat instability,Neurodegenerative diseases,Cell death

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