A facile and rapid preparation of hydroxamic acids by hydroxylaminolysis using DBU as base

Audrey Beillard,Yushma Bhurruth-Alcor,Claire Bouix-Peter, Karinne Bouquet,Sandrine Chambon,Laurence Clary,Craig S. Harris,Corinne Millois,Grégoire Mouis,Gilles Ouvry,Romain Pierre, Arnaud Reitz,Loïc Tomas

Tetrahedron Letters（2016）

引用 16|浏览2

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摘要

•An efficient process to prepare hindered hydroxamic acids from esters is proposed.•Quickest reaction times and best yields were observed when using DBU as the base.•A chromatography-free process using recyclable PS-DBU is also disclosed.•No epimerisation occured when using l-phenylalanine methyl ester as the substrate.

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关键词

Hydroxylaminolysis,Hydroxamic acid formation,DBU

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