FUNCTIONAL EFFECTS OF SCN5A CHANNEL MUTATIONS AND THE RISK OF LIFE-THREATENING EVENTS IN TYPE 3 LONG QT SYNDROME

Yitschak Biton, Neils Otani,Ilan Goldenberg,Elsa Ronzier,Jayson R. Baman,Scott McNitt,Bronislava Polonsky,Jesaia Benhorin,Arthur A.M. Wilde,Peter Schwartz,Michael J. Ackerman,Shimuzu Wataru,Elizabeth Kaufman,Wojciech Zareba,Arthur J. Moss,Coeli M. Lopes

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY（2016）

引用 0|浏览16

暂无评分

摘要

LQT3 syndrome is caused by SCN5A mutations that prolong cardiac repolarization. SCN5A dysfunction can be due to increased sustained currents, but other mechanisms are also observed. We evaluated a possible association between ion-channel dysfunction, arrhythmic risk and response to treatment.We

查看译文

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要