Abstract 10476: Effect of High-dose Oral Multi-vitamins and Minerals in Patients Not Treated With Statins in the Trial to Assess Chelation Therapy

Introduction: Trials of conventional dose vitamin therapy have been largely negative for coronary prevention. TACT studied an ultra-high dose regimen of oral multivitamins and multiminerals (MVM) in post-MI patients. Patients off statins were a pre-specified subgroup. Methods: 1708 patients were randomized in a double-blind factorial trial, to EDTA-based chelation or placebo, and oral MVM or oral placebo. MVM consisted of a 28-component mixture (or placebo), taken as 3 caplets twice daily throughout the 5 year study participation. To our knowledge, the oral antioxidant doses are the highest tested in a clinical trial. The primary endpoint was total mortality, recurrent MI, stroke, coronary revascularization, or hospitalization for angina. The results of oral vitamins versus placebo were not significant [HR (95%CI) 0.89 (0.75,1.07), p=0.212]. However, the pre-specified subgroup of patients not taking statins demonstrated an interaction with MVM (p=0.012). Both unadjusted analyses and comparisons adjusted f...