A Randomized, Double-Blind, Placebo-Controlled, Multi-Center, Cross-Over Study Of Rosuvastatin In Children And Adolescents (Aged 6 To < 18 Years) With Homozygous Familial Hypercholesterolemia (Hofh)

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY(2016)

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摘要
HoFH, a rare genetic disorder, results in extremely elevated serum LDL-C, which accumulates in skin, tendons and arteries, often resulting in CVD before age 20, making treatment starting at the time of diagnosis a necessity. Statins are the primary drugs for the treatment of HoFH and have been
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