Effect of antiretroviral therapy in thromboregulation through the hydrolysis of adenine nucleotides in platelets of HIV patients.

Group untreated HIV: The figure shows an increase in total cholesterol and these patients an increase in activity of the enzyme E-5′-nucleotidase, indicating that the hydrolysis of nucleotide AMP is high. E-ADA activity is decreased indicating that the nucleoside adenosine (Ado) is being accumulated in the extracellular medium for their cardioprotective effects and vasodilators are acting and/or neutralizing the damage caused by HIV.