PLGA-lecithin-PEG-folate core-shell nanoparticles for cisplatin-prodrug targeted delivery

possibilities using macrocyclic host molecules for drug delivery. In one system, for example, anticancer drug doxorubicin functionalized αcyclodextrins (α-CDs) could form complex with double-hydrophilic block copolymers poly(ethylene glycol)-b-poly(2-methacryloyloxyethyl phosphorylcholine) (PEG-bPMPC) block copolymers, leading to formation of pH responsive pseudopolyrotaxane prodrug micelles (Scheme 1, A). It should be noted that this facile strategy could increase the drug content in the micelles due to the fact that α-CD could thread onto PEG chains in a well ordered and high-density manner. Besides, we also developed a facile way to achieve accumulation of nanocarriers in the tumor site by using dual pH responsive pillar[5]arene based supramolecular prodrugmicelles (Scheme 1,B). Results showed that the as-prepared prodrug micelles could be aggregated upon acidic condition, which led to enhanced accumulation and better therapy effect.