A novel protein kinase is essential in bloodstream Trypanosoma brucei

Bryan C. Jensen, Nick Booster,Rama Subba Rao Vidadala,Dustin J. Maly,Marilyn Parsons

International Journal for Parasitology（2016）

引用 4|浏览24

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摘要

•Genetic validation of Trypanosoma brucei protein kinase AEK1.•Lack of inhibitors was overcome by creating an analog-sensitive mutant.•Trypanosoma brucei expressing an analog-sensitive mutant allowed chemical validation in vitro and in vivo.

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关键词

Drug target,Protein kinase,Trypanosome,AGC kinase,Analog-sensitive,In vivo

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