Transcriptional response networks for elucidating mechanisms of action of multitargeted agents.
Drug Discovery Today(2016)
摘要
•Elucidation of a compound's target mechanisms is key to predicting its phenotypic effects.•Computational network pharmacology models provide hypotheses on multi-target mechanisms.•Data-driven models can lead to unbiased findings and novel drug development paths.•Model predictions reduce the number of in vitro and in vivo target validation experiments.•These models also enable systematic discovery of drug repositioning opportunities.
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