Detection Of Sulfatase Enzyme Activity With A Catalycest Mri Contrast Agent

Sanhita Sinharay,Gabriela Fernandez-Cuervo, Jasmine P. Acfalle,Mark D. Pagel

CHEMISTRY-A EUROPEAN JOURNAL（2016）

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摘要

A chemical exchange saturation transfer (CEST) MRI contrast agent has been developed that detects sulfatase enzyme activity. The agent produces a CEST signal at =5.0ppm before enzyme activity, and a second CEST signal appears at =9.0ppm after the enzyme cleaves a sulfate group from the agent. The comparison of the two signals improved detection of sulfatase activity.

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关键词

diagnostic agents,enzyme kinetics,kinetics,NMR imaging,sulfatases

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