A ROLE OF SALMON SOSC1 IN ANTIVIRAL IMMUNITY

true in mammals. In this study, we were interested finding out whether two important salmon pathogenic RNA viruses, salmon alphavirus (SAV) or infectious pancreas virus, were able to modulate SOCS expression in salmon cells lines. We also tested SOCS expression in SAV challenged Atlantic salmon. Furthermore, we asked the questions whether the negative impact of the salmon SOCS1 on IFN signaling would affect virus replication and the expression of ISGs. As important tools for these studies, CHSE-cells overexpressing SOCS1 or SOCS2 were developed and used for both viral infection studies and to measure ISG expression upon stimulation by IFNs. Results for these experiments will be presented and discussed.