Cancer-associated Fibroblasts and Modulation of the Antitumor Immune Response

During tumor progression, tumor cells proliferate under adverse host conditions and use several survival strategies to block the action of key regulators of the immune response and circumvent anti-tumor defenses. Consequently, the current development of new immunotherapeutic strategies aimed at inducing or optimizing the immune response directed against the tumor and opened the way to new treatments of cancers. Besides the several known classical strategies used by tumor cells to escape to immune surveillance, it should be noted that the evasion of immunosurveillance by tumor cells is also under the control of the tumor microenvironment complexity and plasticity [1,2].