Functional analysis of microRNA-122 binding sequences of hepatitis C virus and identification of variants with high resistance against a specific antagomir

    Yi-Ping Li
    Yi-Ping Li
    Van Pham L
    Van Pham L

    Journal of General Virology, pp. 1381-1394, 2016.

    Cited by: 0|Bibtex|Views0|

    Abstract:

    MicroRNA 122 (miR-122) stimulates the replication and translation of hepatitis C virus (HCV) RNA by binding to two adjacent sites, S1 and S2, within the HCV 5′UTR. We demonstrated previously that the miR-122 antagomir miravirsen (SPC3649) suppresses the infection of HCV strain JFH1-based recombinants with HCV genotypes 1–6 5′UTR–NS2 in hu...More

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