Complement gene variants determine the risk of immunoglobulin-associated MPGN and C3 glomerulopathy and predict long-term renal outcome

Paraskevas Iatropoulos,Marina Noris,Caterina Mele,Rossella Piras,Elisabetta Valoti,Elena Bresin,Manuela Curreri, Elena Mondo,Anna Zito,Sara Gamba,Serena Bettoni,Luisa Murer,Veronique Fremeaux-Bacchi,Marina Vivarelli,Francesco Emma,Erica Daina,Giuseppe Remuzzi

Molecular Immunology（2016）

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摘要

•Rare pathogenic variants and a common SNP of THBD predispose to C3 glomerulopathy.•Mutations increase the risk of Ig-MPGN/C3 G only when combined with common SNPs.•Patients with complement gene mutations or C3NeF have a lower risk of ESRD.

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关键词

MPGN,Ig-MPGN,C3G,C3GN,DDD,IF,EM,C3NeFs

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