Population variation in anti-S. aureus IgG isotypes influences surface protein A mediated immune subversion
Vaccine(2016)
摘要
•There is marked variation in anti-S. aureus antibodies between healthy humans.•Serum IgG1 against S. aureus surface antigens declines as adults age.•High anti-S. aureus IgG3 levels bypass bacterial subversion of phagocyte function.•Properties of IgG subclasses should be considered in S. aureus vaccine development.
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关键词
Staphylococcus aureus,Immunosenescence,Antibody,Protein A,Vaccine
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