Evidence by chromatography and mass spectrometry that inorganic nitrite induces S-glutathionylation of hemoglobin in human red blood cells.

Anke Böhmer,Andreas Pich,Mario Schmidt,Arash Haghikia,Dimitrios Tsikas

Journal of Chromatography B（2016）

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摘要

⿢Inorganic nitrite is oxidized in erythrocytes by oxyhemoglobin.⿢This reaction is modulated by thiols.⿢In lyzed erythrocytes nitrite induces S-glutathionylation of hemoglobin on Cysβ93.⿢In addition, nitrite induces S-nitrosylation of hemoglobin.

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关键词

Catalase,Erythrocytes,S-Glutathionylation,Hemoglobin,Mass spectrometry,Methemoglobin,Nitrite,Thiols

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