Involvement of connexin43 in acetaminophen-induced liver injury

Michaël Maes,Mitchell R. McGill,Tereza Cristina da Silva,Chloé Abels,Margitta Lebofsky,Cintia Maria Monteiro de Araújo,Taynã Tiburcio,Isabel Veloso Alves Pereira,Joost Willebrords,Sara Crespo Yanguas,Anwar Farhood,Alain Beschin,Jo A. Van Ginderachter,Maria Lucia Zaidan Dagli,Hartmut Jaeschke,Bruno Cogliati,Mathieu Vinken

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease（2016）

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摘要

•JIC deteriorates upon APAP intoxication in WT mice, which is associated with a switch in mRNA and protein production from Cx32 and Cx26 to Cx43.•The upregulation of Cx43 expression is due, at least in part, to de novo production in hepatocytes.•Cx43+/− animals tend to show increased liver cell death, inflammation and oxidative stress in comparison with WT counterparts.•Hepatic Cx43-based signalling may protect against APAP-induced liver toxicity.

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关键词

ALT,APAP,CD,Cx,ELISA,GJIC,GSH,GSSG,hepaCAM,IFNγ,IL-1β/6/10,n,NAPQI,p,RT-qPCR,SEM,TNFα,WT

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