NMDA RECEPTOR ANTAGONISM BY REPETITIVE MK801 ADMINISTRATION INDUCES SCHIZOPHRENIA-LIKE STRUCTURAL CHANGES IN THE RAT BRAIN AS REVEALED BY VOXEL-BASED MORPHOMETRY AND DIFFUSION TENSOR IMAGING

Huifeng Wu,Wang X, Yanan Gao,Fuchun Lin,T. Song, Y. Zou,L. Xu,Hao Lei

Neuroscience（2016）

引用 22|浏览23

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摘要

•Chronic MK801 treatment induces brain structural changes resembling those in schizophrenia.•MK801-induced atrophy in the cortex and hippocampus is accompanied by neuronal degeneration.•Widespread losses of parvalbumin positive cells observed after chronic MK801 treatment.•Chronic MK801 treatment induces atrophy and diffusion abnormalities in the corpus callosum.

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ANOVA,cc,DA,DG,DR,DTI,ec,FA,FDR,FOV,FWHM,GM,HE,M1,MAM,MBP,MD,MRI,NeuN,NMDAR,PBS,PCP,PNSS,PV,RARE,ROIs,RSD,TR,VBA,VBM,vStr,WM

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