Snai2 and Snai3 transcriptionally regulate cellular fitness and functionality of T cell lineages through distinct gene programs

Peter D. Pioli,Sarah K. Whiteside,Janis J. Weis,John H. Weis

Immunobiology（2016）

引用 6|浏览8

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摘要

•Snai2/Snai3 regulate the competitive fitness of CD8α+, TConv and TReg cells.•Snai2/Snai3 transcriptionally target genes essential to T cell survival and function.•Snai2/Snai3 regulate the TReg transcriptome independent of Foxp3.

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关键词

Snail transcription factors,Autoimmunity,Genetic deficiency,T lymphocyte,T cell receptor

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