Cytotoxicity of mequindox and its metabolites in HepG2 cells in vitro and murine hepatocytes in vivo

Yingchun Liu,Wei Jiang,Yongjun Chen,Yanyan Liu,Peng Zeng,Feiqun Xue,Quan Wang

Mutation Research/Genetic Toxicology and Environmental Mutagenesis（2016）

引用 6|浏览9

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摘要

•The toxicity of MEQ and its main metabolites in vitro in HepG2 cells and in vivo in mouse hepatocytes were investigated.•MEQ could induce cell cycle arrest to the G2/M phase and cause dose-dependent DNA damage in HepG2 cells in vitro and in murine hepatocytes in vivo.•Serious DNA damage in HepG2 cells induced by the metabolites was not observed.

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关键词

Mequindox,Metabolite,Cytotoxicity,HepG2 cell,Hepatocyte

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