Metformin prevents cerebellar granule neurons against glutamate-induced neurotoxicity.

Changwei Zhou,Rong Sun, Sujuan Zhuang,Chongyi Sun,Yongqing Jiang,Yang Cui, Shitou Li, Yanqiu Xiao,Yansheng Du,Huiying Gu,Qingpeng Liu

Brain Research Bulletin（2016）

引用 27|浏览9

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摘要

•Metformin pretreatment protects CGNs against glutamate neuronal toxicity.•Metformin reduces glutamate-induced Caspase 3 activation.•Glutamate-induced JNK and p38 phosphorylation are inhibited by metformin.

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关键词

Metformin,Cerebellar granule neurons,Glutamate,Excitotoxicity,MAPK,Neuroprotection

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